What is the highest mg hydrocodone

Hydrocodone

Hydrocodone or Dihydrocodeinone is an opioid that is structurally related to codeine and, like this, belongs to the derivatives of morphine. As a single preparation (such as Dicodid) it acts as an analgesic (pain reliever) and as an antitussive (cough suppressant). In the USA, the drug is mainly used in combination preparations with paracetamol (such as Vicodin) or ibuprofen.

Drug information ATC code

R05DA03

Drug class

Antitussive

Mechanism of action

Opioid

properties Molar mass299.36 g mol−1Melting point
  • 198 ° C[1]
  • 185-186 ° C (Hydrocodone hydrochloride)[2]
  • 118-128 ° C (Hydrocodone hydrogen tartrate 2,5 hydrate)[2]
solubility
  • bad in water (6.9 g l−1 at 25 ° C)[1]
  • soluble in ethanol and dilute acids[2]
safety instructions Toxicological data

150 mg kg−1 (LD50, Rat, s.c.)[1]

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions.

effect

Side effects

The side effects of hydrocodone include:

application areas

  • Analgesic (pain reliever)
  • Antitussive (cough suppressant)

In patients with otherwise treatment-resistant obsessive-compulsive disorder, observational studies showed a spontaneous reduction in symptoms when taking hydrocodone.[10]

Legal status

In Germany, hydrocodone is subject to the Narcotics Act Annex III and the Narcotics Prescription Ordinance, in the United Kingdom to the Misuse of Drugs Act, in which it is classified in class A (highest level of danger).[11] In Switzerland it is subject to the federal law on narcotics and psychotropic substances.[12]

Trivia

In the doctor series Dr. House does the protagonist Dr. Gregory House (Hugh Laurie) continually hydrocodone (Vicodin) to numb his pain.

In the feature film The Martian, Mark Watney dips a potato into a liquid with the words "I dip this potato in a little Vicodin and nobody can stop me".

See also

Web links

Individual evidence

  1. abcEntry for Hydrocodone in the ChemIDplus database of the United States National Library of Medicine (NLM)
  2. abcEntry on hydrocodone. In: Römpp Online. Georg Thieme Verlag, accessed on June 1, 2014.
  3. ↑ Data sheet Hydrocodone (+) - bitartrate salt from Sigma-Aldrich, accessed on April 4, 2011 (PDF). Template: Sigma-Aldrich / date not given
  4. ↑ ABDA active ingredient dossier: Hydrocodone, retrieved from dimdi.de
  5. ↑ Specialist information Hydrocodone Streuli 5 mg / 10 mg, As of September 2012.
  6. ↑ Mellar P. Davis: Opioids in Cancer Pain. OUP Oxford, 2009, ISBN 978-0-19-923664-0 (limited preview in Google book search), p. 89 ff.
  7. ↑ Eberhard Klaschik: Pain therapy and symptom control in palliative medicine. In: Stein Husebø, Eberhard Klaschik (ed.): Palliative medicine. 5th edition, Springer, Heidelberg 2009, ISBN 3-642-01548-4, pp. 207-313, here: p. 233.
  8. ↑ Eberhard Klaschik: Pain therapy and symptom control in palliative medicine. 2009, p. 233.
  9. ↑ Vicodin, drugs.com, accessed June 3, 2013.
  10. ↑ Joyce Davidson, Throstur Bjorgvinsson: Current and potential pharmacological treatments for obsessive-compulsive disorder. In: Expert Opinion on Investigational Drugs. Volume 12, No. 6, June 2003, pp. 993-1001, doi: 10.1517 / 13543784.12.6.993, PMID 12783603.
  11. ↑ Misuse of Drugs Act 1971: Schedule 2: Controlled Drugs, Part I: Class A Drugs, accessed June 3, 2013.
  12. ↑ Quoted from the Swiss Medicines Compendium.
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